Appleseed ExMachina gives a decent in to those not familiar with the background lore of this Manga and anime: It is the fairly standard set up of rebellious cop (Deunan) reluctantly having to pair up with and adjust to a new partner after her regular old-time partner gets taken out of action. This is a blessing because figuring out what is going on at the beginning without being familiar with the franchise is a tad wee bit difficult especially as the basic plot is a bit muddled.
There are humans like Deunan, cyborgs like Briareos, and first and second generation bioroids who are genetically very close to Deunan. Oddly, Tereus, being a clone of Briareos, has the same memories and feelings for Deunan. This creates a bit of a love triangle, especially since Tereus, being a second generation cyborg is perfectly human looking and looks exactly like what Briareos looked like before he became a machine.
The plot in Appleseed ExMachina has some bioroids launching terrorist attacks for some unknown reason. Meanwhile, Prime Minister Athena of the dream city Olympus wants sole control the earth's satellites so as to control world security. You have to know this is a really bad idea. The story borrows a few elements from Star Trek The Next Generation, especially the Blue Tooth like gizmo trick and some Borg stuff.
The computer animation here is both lush and stilted. Visually it is usually quite pleasing. Olympus looks like a futuristic cross between Tokyo and Times Square. The secondary characters are quite stiff in their movements and expressions while even main characters like Deunan have that computer game style jilting movements at times. Dialogue wise some of the voice actors are also a bit stiff. When it comes to some of the secondary characters, I have seen better acting from Jimmy Fallon and other Saturday Night Live no-hit wonders. The fight scenes are eye candy though.
I found it a bit odd the subtitles did not always match the dialogues. Some of them were really off.
If you are a fan of anime and Manga, Appleseed ExMachina is better than if you are new to this genre.